PML: Pharmacokinetic Modeling Language
 which pharmacokinetic processes are represented as classes. From these classes objects can be created. A set of interconnected PML objects constitutes a PML model. PML models can be used for (Monte Carlo) simulations, parameter fitting and dose calculations. The graph on the left shows a first order absorption input using Below are three real cases and one simulation. The first graph shows a fit of the biphasic absorption of
Midazolam after inhalation. The second graph shows a fit of Ranitidine plasma levels and the observed
effect on stomach pH in intensive care patients. The third graph shows the Ceftazidime plasma levels
and the effect on bacterial growth. The last diagram demonstrates the effect of oral tolbutamide on
glucose dependent endogenous insulin release (type 2 diabetes).
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PML Language |
