Extravascular administered drugs may exhibit complex plasma profiles showing more 

than one local maximum (peak). This is caused by the fact that the passage along

the gastrointestinal tract takes time (lag time) and/or different rates of absorption

at different locations within the gastrointestinal tract. This effect can be observed

with both oral and intranasal formulations. The SimLab Excel application was developed

in close collaboration with University Hospital in Maastricht for the modeling of the dual 

absorption profile observed with intranasal administered midazolam. Models can be

simulated and/or fitted. Models can also be used in Monte Carlo simulations.

                             

                                      Typical dual absorption profile.