Individualized dosage regimen calculations require knowledge on the pharmacokinetic

and pharmacodynamic properties of the drug and the characteristics of the patient. 

A PK-PD-based dosage regimen is not easily and generally applicable, mainly because 

the combination of available PK parameters and therapeutic target levels may be 

inappropriate for the purpose of predicting a plausible dosage regimen. Within the 

project PharmDIS (Pharmacokinetic & Pharmacodynamic Drug Information and Dose

Adjustment System), an alternative approach was chosen, and this PK and standard 

dose-based principle is well suited for computerized dosing advice. PharmDIS aims at the development

of several applications for dosing regimen advice for general practitioners, hospital physicians and 

pharmacists. PharmDIS was funded by the European Commission in the BIOMED 2 (4th framework) and 

IST (5th framework) programmes.