PharmDIS: Drug Information and Dosage Adjustment
![]() Individualized dosage regimen calculations require knowledge on the pharmacokinetic
and pharmacodynamic properties of the drug and the characteristics of the patient.
A PK-PD-based dosage regimen is not easily and generally applicable, mainly because
the combination of available PK parameters and therapeutic target levels may be
inappropriate for the purpose of predicting a plausible dosage regimen. Within the
project PharmDIS (Pharmacokinetic & Pharmacodynamic Drug Information and Dose
Adjustment System), an alternative approach was chosen, and this PK and standard
dose-based principle is well suited for computerized dosing advice. PharmDIS aims at the development
of several applications for dosing regimen advice for general practitioners, hospital physicians and
pharmacists. PharmDIS was funded by the European Commission in the BIOMED 2 (4th framework) and
IST (5th framework) programmes. References
J H Proost, N C Punt (2003). |